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These findings illustrate the potential of TCMs and natural products to beneficially modulate the gut-kidney axis, thereby alleviating AKI and potentially preventing its progression to CKD ( Figure 5 )

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The released mediators would also support neuroinflammation

Competitive Landscape 6.1.1

Watts P, Smith A

The brain also influences kidney function through several key pathways, primarily involving neural, metabolic, and hemodynamic mechanisms, including the SNS, RAAS, HPA axis, and neural circuits and associated feedback loops (Freeman and Wadei, 2015